Il 6 Antibody Cell Signaling

Cytokine growth factor rev.

Il 6 antibody cell signaling. Beekman r touw ip 2010 g csf and its receptor in myeloid malignancy. 1998 biochem j 334 pt 2 297 314. The il 6 soluble il 6rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not il 6rα 3. Neurath mf finotto s 2011 il 6 signaling in autoimmunity chronic inflammation and inflammation associated cancer.

Alternative splicing generates several isoforms with internal deletions some of which exhibit antagonistic properties. Anti interleukin 6 agents are a class of therapeutics interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Click on the other il 6 family cytokines listed below to see the signaling pathways that are activated by each cytokine. Refer to the table below each pathway to see a select list of cytokine expressing cells or tissues and the primary biological effects induced by the different members of the il 6 cytokine family.

The effects of il 2 are mediated through a trimeric receptor complex consisting of il 2rα il 2rβ and the common gamma chain γc 1 2. Il 10 is an important negative regulator of the immune response which allows for maintenance of pregnancy 1. Il 6 shares 39 aa sequence identity with mouse and rat il 6. In contrast increased il 10 levels contribute to persistent leishmania major infections 6.

Il 6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit il 6 r alpha and a signal transducing subunit. Sansone p bromberg j 2012 targeting the interleukin 6 jak stat pathway in human malignancies. Recombinant mouse il 6 mil 6 phe25 thr211 accession np 112445 was expressed in human 293 cells at cell signaling technology. Conversely il 2 is involved in the activation induced cell death aicd that is observed post t cell expansion by increasing levels of fas on cd4 t cells 5.

2004 immunol rev 202. Hence anti il6 agents have been sought. Research studies have shown that il 6 through increasing expression of proangiogenic vegf may also contribute to metastatic breast cancer 5. Background il 6 is a potent inducer of the acute phase response and is produced by t cells macrophages fibroblasts endothelial and other cells 1 2.

In addition il 10 promotes t cell tolerance by inhibiting tyrosine phosphorylation of cd28 4 5. The il 6 soluble il 6rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not il 6rα 3. Il 2rα binds exclusively to il 2 with low. In rheumatoid arthritis they can help patients unresponsive to tnf inhibitors.